Les missions du poste
The last objective of this PhD thesis is to exploit these theoretical developments in the context of selective attenuation of brain oscillations for the treatment of Parkinson's disease. For this disease, gamma brain oscillations (35-80 Hz) are reported to correlate with tremor severity, whereas slower waves (alpha or delta) do not seem to correlate with symptoms. The goal is thus to disrupt pathological oscillations, while leaving healthy activity unaltered. The key idea here is that, on short time-scales, slow brain waves are quasi-static and hence can be assimilated to equilibria. We will thus derive control strategies to make the system 2-contractive while preserving its original equilibria. By doing so, the closed-loop system will be guaranteed to have no limit cycles, yet to keep low-frequency behavior intact. The control law will first be derived by assuming full-state measurement, which is often not compatible with experimental or clinical constraints. We will then rely on the developed observers to estimate the state of the populations inaccessible to measurements, and exploit them for output-feedback policies. 1) Define k-contraction for time-delay systems and build tools to guarantee it in practice
2) Design innovative observers, with finite-time estimation, by exploiting delays
3) Apply these concepts to derive control laws for the selective disruption of brain oscillations.
Le profil recherché
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Based on this theoretical framework, a second objective of this PhD thesis is to derive innovative state observers. Observers can be interpreted as algorithmic sensors: their goal is to estimate hidden state variables by relying only on the measurements available on the system [2]. We propose to purposely add delays in the observer (even when the considered system is delay-free) to obtain better convergence and robustness properties. This approach has already proved efficient in prescribed-time observers design for linear systems [5]. We will extend this methodology to nonlinear systems by using Kazantzis-Kravaris/Luenberger (KKL) observers.
Publiée le 18/04/2026 - Réf : b0a450f9c0d0a1da2143e054418236a2