Principal Dmpk Scientist M - W H/F Servier

Make an impact at the interface of discovery and development

Join Servier's Translational Medicine (TxM) organization to steer programs from early research toward first-in-human, turning robust science into real patient benefit.

You will lead TxM strategy and activities in the project Core Team and represent non-clinical DMPK strategy from late research onward-partnering across ADME/DMPK, non-clinical safety, quantitative pharmacology, formulation, and clinical pharmacology to de-risk and accelerate our pipeline in Oncology and Neurology.

This is a full-time position for our new R&D site in Paris - Saclay with possibility of some remote work.

Responsibilities

As an early TxM lead, the candidate will :

- Be the representative of TxM in the Core Team (CT) in research projects up to clinical candidate selection
- Lead the TxM sub-team and engage with relevant functional experts to ensure project progression
- Be the subject matter expert in ADME/DMPK and/or non clinical safety, ensuring data analysis and interpretation
- Define the TxM and project strategy and lead required work packages; work with Function Managers to form sub-teams to deliver the work packages
- Actively participate in governance meetings (TxM and R&D)
- Support and challenge the CT strategy as integral member of the CT (going beyond the functional TxM expertise - contributor role)
- Communicate to the CT and from the CT to the function (ambassador role) and ensure TxM functional input is reflected in the CT/TxM strategy
- Work in close interaction with project lead and project manager to define and mitigate risks, ensure adherence to project plan (timeline, costs/resources, quality)

As a non-clinical DMPK rep (from late research), the candidate will:

- define the nonclinical DMPK strategy and operational plan of the project in collaboration with the project leader and other functional leads to mitigate risk, and maximize probability of success

- Participate in project team meetings as a recognized DMPK expert

- Provide scientific leadership and training within and outside the team

- Write/Review protocols, scientific reports and prepare appropriate documentation to support regulatory agency filings. Provide DMPK expertise into related documents such as Investigator's Brochures, project strategic documents and study reports

- Follow external scientific advances in the area of drug metabolism and pharmacokinetics and promote and implement relevant technologies & methods internally to ensure state-of-the-art capabilities and continuous support for projects
- Ensure good communication with other partners in the project team and sub-teams (non-clinical safety, Pharmacology, Quantitative pharmacology, Clinical pharmacology, early formulation, ....). Interact with those teams in a matrix environment
- Participate actively in operational performance monitoring by ensuring that resources and timelines are met for deliverables for which there is a contribution or accountability

Profile :

- Ph. D. degree (or equivalent experience) in chemistry, pharmacology or related discipline
- Strong experience in DMPK field in Drug Discovery and Development Programs
- Experience in multiple drug modalities (ASOs, Protacs, NBEs) is an asset
- Experience in interacting with external partners and contract research organizations (CROs) is a plus

Good understanding of drug discovery programs and in depth understanding of structure property relationships in ADME and toxicology

- Experience in drug discovery, drug design and multi-parameter optimization with a drug hunter mindset
- Good understanding of in silico ADME and toxicity prediction tools and their application to drug design
- In depth knowledge of the DMPK discipline and a good knowledge of non-clinical safety assessment
- Experience in application of Artificial Intelligence driven approaches to drug discovery and development is a plus

Strong DMPK experience in drug development programs and regulatory interactions

Experience in drug-drug interaction assessment, biotransformation (including Metabolites in Safety Testing) and relevant methodologies and approaches

Communication skills

- Excellent communication, presentation, interpersonal skills, with an ability to inform, influence, and persuade
- Assertiveness, ability to influence decision making in project core teams to facilitate project progression
- Ability to work independently to drive project forward as well as collaboratively in a multidisciplinary team (matrix) environment
- Good listening and writing skills in English

Nous sommes engagés pour l'égalité des chances et le développement des talents dans toute leur diversité. Nous accordons autant de valeur à l'expérience qu'à l'envie de s'engager au quotidien pour être utile au progrès thérapeutique au bénéfice des patients. Si vous vous reconnaissez dans cette offre et ces quelques lignes, saisissez cette opportunité de nous rencontrer.