Senior Clinical Pharmacologist- CDI H/F Pierre Fabre

Son portefeuille compte plusieurs franchises médicales et marques internationales dont Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Eau Thermale Avène, Klorane, Ducray, René Furterer, A-Derma, Naturactive et Pierre Fabre Oral Care.

Implanté depuis toujours en région Occitanie, fabricant plus de 95% de ses produits en France, le groupe emploie près de 10 000 collaborateurs dans le monde et distribue ses produits dans quelque 130 pays. Pierre Fabre est détenu à 86% par la Fondation Pierre Fabre, une fondation reconnue d'utilité publique, et secondairement par ses collaborateurs à travers un plan d'actionnariat salarié.

En 2021, Ecocert Environnement a évalué la démarche de responsabilité sociétale et environnementale du Groupe selon la norme ISO 26000 du développement durable et lui a attribué le niveau « Excellence ».

Pierre Fabre est reconnu comme l'un des « Meilleurs Employeurs du Monde 2021 » par Forbes. Notre groupe est classé dans le Top 6 de l'industrie cosmétique et dans le Top 7 de l'industrie pharmaceutique dans le monde. Nous sommes convaincus que notre engagement et notre passion font préserver notre indépendance et vivre notre raison d'être.

Votre mission

We are seeking a Senior Clinical Pharmacologist to join the Pharmacokinetics and Toxicology team within the Pierre Fabre R&D Pharma in Toulouse to support clinical programs in oncology, dermatology and rare diseases (Langlade site, Oncopole, France).

Your role within a pioneering company in full expansion:

Project Leadership & Strategy

• Lead the clinical pharmacology strategy as the PK representative in multidisciplinary project teams.
• Lead the IND phase including translational dose setting
• Define study needs, timelines, and budgets for key development phases (e.g., FIH, Ph2/3, NDA submissions).
• Contribute to the evaluation of external assets, offering expert opinions to support business decisions.

Scientific & Operational Expertise

• Oversee the design and execution of clinical and pharmacometric studies.
• Oversee the design and execution of preclinical studies during the IND phase
• Collaborate closely with clinicians, statisticians, pharmacologists, toxicologists, CMC experts, and regulatory specialists.
• Partner with CROs, KOLs, and business partners to ensure successful study outcomes.

Documentation & Regulatory Interactions

• Author scientific and regulatory documents, including study protocols, investigator brochures (IB), IND/IMPD, NDA submissions, and risk management plans (RMPs).
• Represent the company in meetings with regulatory authorities, technical experts, and external stakeholders.

This position is compatible with teleworking up to 2 days a week according to company rules.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation...

Qui êtes-vous ?

Your skills at the service of innovative projects:

PhD, MD, or PharmD in pharmacokinetics, pharmacometrics, or a related scientific discipline with a minimum of 4+ years of industry experience in clinical pharmacology and drug development,
- Proven track record of supporting drug development from early clinical phases (Ph1 /2/3) through regulatory submissions, preferably in oncology, dermatology or rare diseases.

Expertise:
- In-depth knowledge of PK/PD study design, analysis, and interpretation (NCA, PBPK, PopPK, modeling).
- Proficiency in pharmacometric software (e.g., WinNonlin, NONMEM, GastroPlus, SimCYP, R).
- Strong understanding of EU and US regulatory requirements related to the IND phase and clinical pharmacology.

Skills & Competencies:
- Strong analytical thinking and problem-solving skills.
- Ability to collaborate effectively within cross-functional teams and build productive external relationships.
- Excellent communication skills, both written and spoken, in English (French is a plus).

Nous sommes convaincus que la diversité est une source d'épanouissement, d'équilibre social et de complémentarité pour nos collaborateurs, nos offres sont donc ouvertes à toutes et tous sans restriction.