Postdoctoral Fellow In Computational Medicine H/F Servier

Who are we? 22,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

www.servier.com

Are you a dynamic and innovative researcher passionate about advancing cancer treatment through data science? We are seeking a postdoctoral fellow to join our translational medicine research team, focusing on deciphering and modeling therapy resistance. This is a unique opportunity to play a crucial role in understanding intra-tumoral heterogeneity in Acute Myeloid Leukemia patients by applying pioneering AI-based approaches at the intersection of multi-OMIC characterization and disease understanding.

Why Join Us?

- Impactful Research: Investigating intra-tumoral heterogeneity is critical to uncovering why treatments fail in AML. By integrating multi-omics data with and without temporal components, you will uncover the molecular and cellular mechanisms underlying disease progression and treatment resistance.
- Innovative Environment: Lead efforts in benchmarking and applying AI-driven methods to scRNA-seq analyses. You will have the chance to annotate cell clusters, identify malignant populations, and reconstruct clonal phylogenies to understand evolutionary dynamics across patient response status.
- Collaborative Team: Work in an environment that bridges the gap between data science and clinical application, featuring frequent interactions with internal R&D and IT teams to ensure research alignment with broader organizational goals.

Responsibilities:

- Self-document on state-of-the-art methods of interest for the project.
- Implement, benchmark, and share appropriate methodologies in R or Python for the purpose of the project.
- Perform comprehensive multi-omic data analysis to characterize and model relapse-specific tumor clones.
- Identify biomarkers or predictive signatures associated with therapy resistance.
- Synthesize and interpret analyses in written reports in English.
- Share selected project outcomes through scientific publications in peer-reviewed journals, posters, and/or oral presentations at conferences.
- Collaborate with cross-functional teams (R&D, IT) to ensure integration of research efforts.

Profile:

- PhD in Bioinformatics, Biostatistics, or Data Science, with demonstrated expertise in singlecell omics data analysis.
- Handson experience with singlecell sequencing technologies (e.g., scRNAseq, proteogenomic) and comfort working with complex, highdimensional datasets.
- Proven experience in developing data science (Machine Learning, AI) applications for translational research projects.
- Excellent skills in R and/or Python, including code sharing and versioning.
- Proficiency with Linux environments, HPC, and cloud computing.
- Good knowledge of molecular biology and proven experience in single-cell data analysis for oncology.
- Scientific level English (written and spoken).
- Ability to work closely with multidisciplinary teams with good organization and communication skills.

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!