Post-Doctoral Fellow In Cancer Biology H/F Servier

Who are we? 22,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

www.servier.com

Job Title: Post-Doctoral Fellow in Cancer Biology (H/F)

Are you a dynamic and innovative researcher passionate about advancing cancer treatment? We are seeking a post-doctoral fellow to join our oncology drug discovery team, focusing on hard-to-treat cancers. This is a unique opportunity to play a crucial role in replenishing our drug discovery pipeline, particularly in the early stages, by identifying novel targets and targeting cancer-specific mutations.

Why Join Us?

- Impactful Research: The tumor suppressor TP53 is the most commonly mutated gene in cancer, with mutations prevalent in 20-75% of oncology diseases and associated with poor prognosis. There are currently no targeted treatments for patients with TP53 mutations, highlighting a significant medical need and an area ripe for creative strategies.
- Innovative Environment: Lead efforts to identify and target novel cancer-specific mutations, particularly those involving TP53, making a significant impact in oncology by addressing critical unmet medical needs.
- Collaborative Team: Work alongside cross-functional teams to ensure alignment and integration of research efforts with broader organizational goals.

Responsibilities :

- Develop and implement strategies for setting up 2D and 3D cultures and assay conditions to select human cell lines for cellular screening and cell painting.
- Execute primary and secondary screens to identify potential drug candidates.
- Characterize bioactive molecules to evaluate their potency, specificity, selectivity, and early signs of efficacy and toxicity.
- Conduct cellular target deconvolution to identify novel targets and develop drugs specifically targeting cancer mutations.
- Study the mechanism of action of molecules, including cell death signaling pathways.
- Collaborate with cross-functional teams to ensure research efforts align with organizational goals.
- Propose new ideas and targets based on literature or personal research findings.
- Actively follow literature on the subject.
- Present research findings at internal meetings.
- Prepare and publish protocols and scientific manuscripts under the direction of the manager.
- Comply with health and safety rules and required quality standards.

Profile :

- PhD in oncology, cancer cell biology, cell biology, or biotechnology.
- Strong experience in cell biology, pharmacology, and confocal imaging.
- Prior experience in in vitro cancer models and cancer cell signaling.
- Experience with medium throughput screening technologies and robotic platforms in 384-well format is appreciated.
- Experience in high-content screening and imaging data analysis is appreciated.
- Proven research record, including conceptual work that resulted in a first-author publication (or in the process of publishing).
- Mastery of oral and written English.
- Autonomous, proactive, rigorous, reliable, motivated, scientifically and technologically curious, and a committed team player.

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!